Madam Therapeutics

News Archive

Feature Article on Madam Therapeutics and LUMC partnership in the Health~Holland Update September 2017

In an interview in the September issues of the Health~Holland Update, Remko Van Leeuwen, CEO of Madam Therapeutics tells about how the PPP Allowance from the Dutch government has strengthened the collaboration with the LUMC during the fundamental stages of their collaborative research. While describing that it can be challenging for a company to be involved in the research at such an early time point, this PPP allowance mechanism provides the extra support for such collaboration. In fact, Van Leeuwen explains that he believes it can be very helpful for parties to initiate first contact between a company and a research organisation before jointly starting an R&D project.

The full interview can be viewed here

CEO Madam Therapeutics interviewed on Dutch Radio Show

On September 1st, Remko van Leeuwen CEO of Madam Therapeutics, gave a pitch and was interviewed on the “Zaken doen met” radioshow on the Dutch Radio Station BNR. “Zaken doen met” is advertised as the most entrepreneurial radioshow of the Netherlands. During the interview, Remko van Leeuwen explains the urgent need for new antimicrobial agents, and talks about the opportunities and difficulties he experiences as entrepreneur of a small biotech company. A replay of the interview can be listened to (in Dutch) via

AMR Industry Alliance announces to fight antimicrobial resistance

An international association of pharmaceutical, biotechnology, and diagnostics companies today announced the formation of a new alliance to monitor and drive industry efforts to fight antimicrobial resistance (AMR). The AMR Industry Alliance aims to bring together stakeholders from the life sciences industry to ensure progress is made on their commitments to reduce the development of antimicrobial resistance, invest in research and development, and improve global access to antimicrobials, diagnostic tests, and vaccines. Read more….

Leonie de Best, CBO of Madam Therapeutics, is in Paris to engage in B2B meetings at BioEquity Europe 2017

Leonie de Best, CBO of Madam Therapeutics, traveled to Paris today to be at the BioEquity Europe 2017 meeting, which is held 22-23rd May. If you are attending the conference and would like to book an appointment to meet with us, please email us on


Antibiotic resistance has a language problem -standardize the terminology for a better global response

Clinicians have long known that microbes such as bacteria, viruses and fungi are becoming alarmingly resistant to the medicines used to treat them. But a global response to this complex health threat — commonly termed ‘antimicrobial resistance’ — requires engagement from a much broader array of players, from governments, regulators and the public, to experts in health, food, the environment, economics, trade and industry.

A recent editorial in Nature, describes that people from these disparate domains are talking past each other. Many of the terms routinely used to describe the problem are misunderstood, interpreted differently or loaded with unhelpful connotations.

A 2015 survey by the World Health Organization (WHO) in 12 countries highlighted people’s unfamiliarity with the language of antibiotic resistance2. Fewer than half of the nearly 10,000 respondents had heard of the term ‘antimicrobial resistance’. Only one-fifth were aware of its abbreviated form ‘AMR’. By contrast, more than two-thirds knew of the terms ‘antibiotic resistance’ or ‘drug resistance’. A similar study published the same year of people in the United Kingdom — by the UK biomedical charity the Wellcome Trust — revealed comparable trends

The interchangeable use of terms by the press and by scientists in publications and meetings is likely to be counterproductive in all sorts of contexts. Take food production. In recent years, different sectors have called on countries to phase out or abolish the ‘antimicrobials’ used to promote animal growth, to protect humans from increasing levels of drug-resistant bacteria4.

Simple, clear and unambiguous terminology would help to ensure that the global effort against drug resistance is focused on the greatest immediate challenge: the rise of drug-resistant bacteria that cause common illnesses, resulting from the high use of antibiotics by humans. It could also improve people’s understanding and engagement.

Read more

Madam Therapeutics at the 18th BioEquity Europe Meeting, Paris, France

Madam Therapeutics will be at the BioEquity Europe 2017 meeting, to be held between the 22-23rd May in Paris, France. If you are attending the conference and would like to book an appointment to meet with us, please email us on

Madam Therapeutics has been nominated for Most Innovative Antibiotic Treatment Company by European CEO Magazine

Madam Therapeutics has been nominated for Most Innovative Antibiotic Treatment Company  2017 by European CEO Magazine. With this award, they celebrate leading players across a range of sectors. Announcement of the European CEO 2017 award winners will be made early January 2018.

US patent No. 9,562,085 grant for SAAP-10.

Madam Therapeutics is proud to announce that the United States of America patent for SAAP-10 was granted on 7 February 2017 bearing patent No. 9,562,085. The patent assignment for our lead peptide SAAP-148 is anticipated in 6 months time.

NADP takes the next step towards new antibiotics and alternatives


The Netherlands Antibiotic Development Platform (NADP) will be launched in April. The new platform facilitates the collaboration between public and private organisations, to enhance the development of new antibiotics and alternative therapies for infectious diseases in humans and animals.

NADP will identify relevant research groups, institutes and companies involved in chemical, biological, and/or biomedical antibiotic research to forge collaborations through targeted connections and will organise regular meetings with interested parties. At a later stage, the NADP will provide Drug Discovery Management support/vouchers and Intellectual Property and Technology Transfer Office support.

Within the Netherlands Antibiotic Development Platform (NADP), knowledge institutions and the business community will work together to develop new antibiotics and alternatives. The core mission of NADP is to bring companies and research groups together to accelerate research into the development of new antibiotics and alternatives to antibiotics.

Madam Therapeutics welcomes this very important initiative in the Netherlands, and congratulates the initiators with this achievement. In the upcoming years, Madam Therapeutics will contribute this expertise to the NADP to accelerate the R&D in new antibiotics, and alternative and preventive treatments for bacterial infections in humans and animals.

BioWorld Today: Antimicrobial peptides (AMPs) are amongst the most exiting developments in the antimicrobial development space today

BioWorld Today, one of the leading news sites for the biotech industry from Thomson Reuters, has labelled Antimicrobial peptides (AMPs), such as SAAP-148 that is developed by Madam Therapeutics, as one of the exiting developments in the anti-microbial development space.

“Antimicrobial resistance (AMR) is a topic that just won’t go away, and for good reason”, according to BioWorld. “Despite the plethora of threats facing humankind, including thousands of diseases in need of therapies or cures, many scientists worry that the biggest risk of extinction comes from the deadly pathogens that exist in uneasy cohabitation on planet Earth”.

Tensions mounted in 2015 after the mcr-1 gene was detected on plasmids in China and Europe and were heightened last year with the first U.S. case of a patient with an infection resistant to a last-resort antibiotic. But academics remain hard at work, and more small companies are moving into the space. Antimicrobial peptides (AMPs) – like SAAP-148- in particular – are among the newest kids on the block.

BioWorld Today highlights that AMPs have shown the ability to kill a broad spectrum of gram-negative and gram-positive bacteria, enveloped viruses, fungi and even cancerous cells. AMPs also may offer the prospect of enhancing immunity by functioning as immunomodulators.